lundi 29 juillet 2013

Better Drug Delivery Through Liposome

By Irma Farrell


Drug delivery has bothered scientist with increasing need for specificity. Vehicles used in delivery require different designs and structures to make them effective. Liposome is favored because it has shown an admirable ability to be specific unlike traditionally used vehicles. Scientist are looking at something that has a high payload, reduces circulatory time through stealth operation, enhances uptake, has reduced side effects and is specific on receptors.

Incredible results have been obtained from testing liposomes over the years. They have shown a great deal of potential that scientists seek to utilize. Some of the admirable aspects with liposomes include enzyme resistance during metabolism, high solubility as well as specificity. Researchers are narrowing down on this element.

The structure and design of liposomes make drugs that are encapsulated using the compounds to be easily absorbed in the body. They are flexible making it easier to control release of important elements in the body. There is reduced toxicity because lower dosages are administered. This means that side effects are reduced. It is the preferred mode of delivering gene therapy drugs.

There is an effect when one considers the sizes of liposomes required to deliver the drugs. This translates into reliable efficacy considering that circulation in the blood and residence are enhanced. Target drugs are easily absorbed by body organs and their efficacy enhanced. This has a bearing on the effectiveness of the drug. Getting a specific size is the current focus in most of the studies to boost effectiveness.

Getting an expert in solution development and manufacture depends on experience and dedication. You will get a solution that is customized for the project at hand. There are a variety of lipid and liposomal solutions provided for the market. Other solvents and surfactants are used in optimizing existing solutions.

Solutions are developed using elaborate procedures that include semi-continuous, batched and scalable. The latest equipment are used to increase accuracy and ensure effectiveness. The processes used make it easy to scale these solutions to meet heavy industrial demands. Sterilization and purifications are also carried out. Tangential flows are used during purification. Other available services include homogenization using high pressure as well as extrusion. This will facilitate sizing and solution preparation.

There is a package for such processes as solvent injection, lipid hydration, aseptic processes as well as lyophilization. Liposomal analysis is carried out to determine particle distribution and sizes. Related procedures include electron microscopy, encapsulation efficiency testing and determination of zeta potential. Drug loading is offered in this package.

A reliable company will deliver good results depending on the track record and commitment to meet customer demands. Diversity of the compounds they are dealing with is an indication of capability and should be considered as well. All the solutions will be developed and manufactured within the same factory reducing the possibility of errors and variations.

Liposome is preferred because it avoids detection by body enzymes. It is favored because of its nature to target specific areas. Drugs that are naturally toxic will be delivered easily using a specific mechanism. This specificity will be designed during construction.




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