lundi 4 février 2013

Liposome Allows The Best Drug Delivery Way

By Gabrielle Lambert


There are three types of them. Multilamillar vesicles or shorter MLV, small unilamellar vesicles or SUV and LUV, or large unilamellar vesicles. They are all used for delivery of different drugs. It is usually designed as model for artificial cell, but liposome can deliver drugs in other ways as well. Their specific shape and other qualities make them very useful transferring method on numerous fields, especially in medicine. They can be inhaled as a dry powder, in form of nasal spray, hydro gel or even cream or lotion, or taken intravenously.

There are so many fields where they can be used, for example in food industry, agriculture or cosmetology. They are highly efficient carriers of all types of enzymes and supplements, and thanks to the fact they are actually very similar to the real cells, they have very high biocompatibility, comparing to any other carrier. It lowers the chances for different side effects, as well as improving the diffusion and absorption of the particular drug.

It is really a tiny bubble with the membrane composed from the same, or very similar elements the cell is composed from, called phospholipids. Thanks to that, they can safely deliver their contents on the targeting area. It is very useful in cancer treatments, for example. Those little capsules can target the tumor, penetrate through its membrane and safely deliver the drug, without causing damage to surrounded tissue.

Liposomes can even transfer very large fragments of DNA, and to deliver genes to cells. At the same time, those pieces of DNA are very well protected within these bubbles, safe from all types of degrading processes. Capsules can be lipophilic, hidrophilic or both, and thanks to their bi-layered membranes, they can carry positively, but also negatively charged molecules.

The method of delivering can highly affect the final drug absorbing. Various anticancer drugs will show much higher efficacy if this carrier method is used. Drug circulation is significantly prolonged, and the retention potential become much higher. Hydrolysis and drug solubility may affect the drug effectiveness, and this way this problem can be easily solved.

Recently, liposomes became very interesting for the specific oral delivery of different nutritional supplements. The majority of dietary and nutritional supplements in form of pills and capsules have very low level of absorption. Furthermore, traditional oral tablets are partially destroyed by the gastric system, losing their effectiveness.

Using them as the carriers for all types of dietary and nutritional supplements is much better solution. It is more effective way of delivering them to the cells and tissues. This form of transferring both lipophilic and hydrophilic nutrients within small, natural capsules bypasses the gastric system and has significantly higher level of bioavailability, as well as absorption. The drug inside those capsules is better protected, and the product is more effective.

Nano liposomes are even smaller than those mentioned before, and have significantly higher efficacy. Of course, different factors affect the final quality, for example, the material used in process of production, the latest technology, size and some other conditions. The most important thing is to produce the adequate version for each particular purpose. In conclusion, liposome might change the drug industry very soon.




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